Development of Aplastic Anemia during Treatment of Anaplastic Astrocytoma with Temozolomide
نویسندگان
چکیده
منابع مشابه
Treatment of Aplastic Anemia.
There is general agreement that in children and adolescents with an HLA-identical or syngeneic sibling, bone-marrow transplantation (BMT) should be performed without delay. More controversial are young-to-middle-aged adults with an HLA-identical sibling. Because of comparable survival rates, some centers advocate BMT; others advocate immunosuppression as primary treatment. BMT cures severe apla...
متن کاملTemozolomide Salvage Chemotherapy for Recurrent Anaplastic Oligodendroglioma and Oligo-Astrocytoma
OBJECTIVE To evaluate the efficacy of temozolomide (TMZ) chemotherapy for recurrent anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA). METHODS A multi-center retrospective trial enrolled seventy-two patients with histologically proven AO/AOA who underwent TMZ chemotherapy for their recurrent tumors from 2006 to 2010. TMZ was administered orally (150 to 200 mg/m(2)/day) f...
متن کاملAplastic anemia with concurrent temozolomide treatment in a patient with glioblastoma multiforme.
Temozolomide (TMZ) is an oral alkylating agent used during concurrent and adjuvant chemotherapy for newly diagnosed glioblastoma multiforme. Temozolomide is generally well tolerated and improves survival; however, severe adverse events have occasionally been reported. Here, we report the case of a patient who developed aplastic anemia with related complications in the setting of concurrent TMZ ...
متن کاملEffectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma
BACKGROUND Malignant gliomas recur even after extensive surgery and chemo-radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against recurrent glioma, the effects last only a few months and drug resistance develops thereafter in most cases. Induction of O6-methylguanine-DNA methyltransferase (MGMT) in tumors is considered to...
متن کاملTreatment of aplastic anemia with nandrolone decanoate.
Highly satisfactory results obtained with improvement was seen in two still under 50 mg./week nandrolone decanoate treatment. Once therapy had been com(Deca-Durabolin) for 3-16 months are menced, there was a period of latency reported in 10 cases of aplastic anemia. which fluctuated between 1 and 9 In the series thus treated there were only months. Except for one patient with two deaths, occurr...
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ژورنال
عنوان ژورنال: Case Reports in Oncology
سال: 2020
ISSN: 1662-6575
DOI: 10.1159/000509744